Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Sympathetic nerve activity in obstructive sleep apnoea.

K Narkiewicz1, V K Somers

  • 1Department of Hypertension and Diabetology, Medical University of Gdańsk, Debinki, Poland.

Acta Physiologica Scandinavica
|March 1, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The impact of war on the development and progression of arterial hypertension and cardiovascular disease: protocol of a prospective study among Ukrainian female refugees.

Frontiers in cardiovascular medicine·2024
Same author

The phenomenon of HbA1c stability and the risk of hypoglycemia in long-standing type 1 diabetes.

Diabetes research and clinical practice·2019
Same author

Diagnostic accuracy of body mass index to identify obesity in older adults: NHANES 1999-2004.

International journal of obesity (2005)·2015
Same author

Differential effects of leptin on adiponectin expression with weight gain versus obesity.

International journal of obesity (2005)·2015
Same author

Wavelet transform analysis to assess oscillations in pial artery pulsation at the human cardiac frequency.

Microvascular research·2015
Same author

CrossTalk opposing view: Which technique for controlling resistant hypertension? Carotid chemoreceptor denervation/modulation.

The Journal of physiology·2014

Obstructive sleep apnoea (OSA) elevates sympathetic nerve activity, contributing to cardiovascular disease risk. Continuous positive airway pressure (CPAP) treatment can reduce this activity, highlighting OSA

Area of Science:

  • Cardiology
  • Sleep Medicine
  • Autonomic Neuroscience

Background:

  • Obstructive sleep apnoea (OSA) is increasingly linked to cardiovascular disease (CVD).
  • Autonomic nervous system dysfunction, particularly sympathetic overactivity, is implicated in the OSA-CVD connection.
  • The precise mechanisms linking OSA to CVD remain incompletely understood.

Purpose of the Study:

  • To explore the role of autonomic mechanisms, specifically sympathetic nerve activity, in the relationship between OSA and cardiovascular disease.
  • To understand how OSA contributes to sustained sympathetic drive and elevated blood pressure.
  • To evaluate the impact of continuous positive airway pressure (CPAP) on sympathetic activity in OSA patients.

Main Methods:

  • Review of studies investigating sympathetic nerve traffic in OSA patients.

Related Experiment Videos

  • Analysis of physiological mechanisms including chemoreceptor and baroreceptor reflexes.
  • Examination of humoral factors like endothelin and endothelial function.
  • Assessment of the effects of long-term CPAP treatment on sympathetic activity.

    • Main Results:

    • Patients with OSA exhibit consistently high sympathetic nerve activity, even during wakefulness.
    • Repetitive hypoxia and hypercapnia during sleep increase sympathetic drive via chemoreceptor reflexes.
    • Mechanisms contributing to sustained sympathetic activity include baroreflex dysfunction, altered cardiovascular variability, and endothelial dysfunction.
    • Long-term CPAP treatment effectively reduces muscle sympathetic nerve activity in OSA patients.

    Conclusions:

    • OSA significantly contributes to elevated sympathetic drive and blood pressure, potentially augmenting hypertension in many patients.
    • Undiagnosed OSA may play a role in the metabolic and cardiovascular complications associated with obesity.
    • Targeting OSA through treatments like CPAP can mitigate sympathetic overactivity and associated cardiovascular risks.