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Updated: Aug 8, 2026

Non-invasive Assessments of Subjective and Objective Recovery Characteristics Following an Exhaustive Jump Protocol
Published on: June 8, 2017
[Cryotherapy with nitrous oxide in primary care]
C Menéndez Villalva1, T Gamarra Mondelo, R Fernández Alvarez
1Centro de Saúde Mariñamansa-A Cuña. Servicio Galego de Saúde. Ourense. España. carmevill@eresmas.com
Objective:
To study the efficacy, tolerance and safety in primary care of the cryotherapy technique using nitrous oxide. Design. Descriptive, observational and transversal study.
Setting:
Mariñamansa-A Cuña Health Centre, Ourense.
Participants:
All the patients who consulted for cutaneous lesions caused by cryotherapy between March and April 2000 (n=130).
Main Measurements:
Age, sex, diagnosis, location, size of lesion, duration of application of the cryogenic agent, previous treatment, side-effects observed, and evolution of the lesion.
Results:
Mean age was 36.65 (95% CI, 32.57-40.74), of whom 53.8% (95% CI, 44.80-62.50) were women. The most common lesions were common warts (68.5%), actinic Keratosis (12.3%) and plantar warts (7.7%). We found that most lesions were located on an upper limb (50.8%). The mean size of lesions was 8.65 mm2 (95% CI, 4.50-12.80). 69.7% of warts were scraped prior to cryotherapy; and 16.2% received prior keratolysis. We found no side-effects in 32.3% of the patients; the commonest side-effect detected was blisters. Mean number of cryotherapy sessions was 2.82 (95% CI, 2.39-3.29). The technique was tolerated well in 83.8% of cases. We found total cure in 87.7%. Most of the cutaneous lesions that failed were common warts.
Conclusions:
Nitrous oxide is effective in most lesions caused by cryotherapy. The technique is tolerated well, can be handled easily and can be used in primary care.
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