Psychosocial and Neurobehavioral Factors Related to Surgical Treatment for Partial Epilepsy: A Multivariate Analysis

Studies of temporal lobe surgery rarely include anatomical and neurobehavioral data in the analysis of outcome. We carried out a retrospective study on 50 patients, using clinical data from case notes, resection volumes, and preoperative imaging data. Three main conclusions emerge from this study: (1) Psychosocial outcome is related to postoperative seizure control. (2) Late postoperative aggression and clinical depression are associated with bad psychosocial outcome. (3) Right-sided hippocampal sclerosis, as suggested by measurements with T2 relaxometry, correlates with interictal psychopathology, as measured with the Beck Depression Inventory, the Leyton Obsessional Inventory, and the Bear-Fedio personality inventory.