Related Experiment Video
Updated: Aug 17, 2026

Electroconvulsive Seizures in Rats and Fractionation of Their Hippocampi to Examine Seizure-induced Changes in Postsynaptic Density Proteins
Published on: August 15, 2017
Treatment of sexual disorders in people with epilepsy
1Department of Neurology and Neuroscience, Comprehensive Epilepsy Center, Weill Medical College of Cornell University, 525 East 68th Street, Room K-615, 10021, New York, NY, USA
Abstract:
Sexual dysfunction is underreported in persons with epilepsy. The evaluation of sexual physiology in small samples of epilepsy patients shows abnormal sexual functioning, and points to low free testosterone levels as a contributing factor. Abnormal sexual physiology in epilepsy patients may be due to antiseizure medication-related altered testosterone metabolism and abnormal central gonadotropin secretion due to epileptic physiology in the brain. More information exists on the sexual side effects of "classic" antiseizure medications than the "new generation" of antiseizure medications; barbiturates appear to have the greatest risk. More active surveying for sexual dysfunction should be undertaken in epilepsy clinics; a simple, self-reported scale of sexual functioning is available. Testosterone replacement for men, dehydroepiandrosterone for women, and sildenafil for restoring sexual performance are appropriate.
Related Concept Videos
Epilepsy and Seizures: Overview
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
Antiepileptic Drugs: Calcium Channel Blockers
Calcium channel blockers exert their antiepileptic effects by targeting T-type calcium channels, which are integral to transmitting nerve signals in the central nervous system. These channels allow the passage of calcium ions, which are vital for neuronal communication. By inhibiting T-type calcium channels, calcium channel blockers effectively reduce the release of neurotransmitters and...
Antiepileptic Drugs: Glutamate Antagonists
Antiepileptic Drugs: Potassium Channel Activators
Ezogabine has gained approval as an adjunctive treatment...
Electroconvulsive Therapy
Epilepsy ll: Types

