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Updated: Sep 27, 2026

Grafting of Beads into Developing Chicken Embryo Limbs to Identify Signal Transduction Pathways Affecting Gene Expression
Published on: January 17, 2016
The expression patterns of c-kit and Sl in chicken embryos suggest unexpected roles for these genes in somite and
Mark V Reedy1, Randy L Johnson, Carol A Erickson
1Section of Molecular and Cellular Biology, University of California at Davis, Davis, CA 95616, USA. mreedy@creighton.edu
Abstract:
We have used whole-mount in situ hybridization to investigate the patterns of c-kit and Sl expression in stage 11-22 chicken embryos. Our analysis shows that c-kit and Sl are expressed quite differently in chicken embryos compared to the reported expression patterns of these genes in embryos of other taxa. Most notably, chicken c-kit is expressed in primordial germ cells as well as in the developing somite, the apical ectodermal ridge, and in the early foregut endoderm. Sl is expressed in the lateral and intermediate mesoderm and in extraembryonic membranes. These data suggest that chicken c-kit and Sl may play novel and unexpected roles in somitogenesis, limb development, and foregut development in avian embryos.
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