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Updated: Sep 27, 2026

Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death
09:18

Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death

Published on: December 27, 2016

[Current concepts on apoptotic signalling pathways: new targets for anticancer strategies]

Evelyne Ségal-Bendirdjian1, Josette Hillion, Chafké Ahmed Belmokhtar

  • 1Inserm U496, Centre G. Hayem, Hôpital Saint-Louis, 1, avenue Claude-Vellefaux, 75010 Paris. esegal@juputer.chu-stlouis.fr

Bulletin Du Cancer
|March 1, 2003
PubMed

Insights

Apoptosis, programmed cell death, is vital for development and homeostasis. Understanding its molecular pathways aids in developing new anticancer strategies and optimizing existing drug therapies.

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Context:

  • Apoptosis is a fundamental physiological process crucial for organismal development and maintaining cellular balance.
  • Dysregulation of apoptosis is implicated in the development of cancer and resistance to therapeutic drugs.
  • Multiple, independent signaling pathways meticulously control the process of apoptosis.

Purpose:

  • To elucidate the molecular mechanisms underlying apoptosis.
  • To provide a foundation for developing rational anticancer strategies.
  • To explore novel therapeutic approaches targeting apoptotic pathways.

Summary:

  • Apoptosis, or programmed cell death, is a tightly regulated process essential for development and homeostasis.
  • Defects in apoptotic pathways can lead to cancer development and drug resistance.
  • Understanding these molecular events is key to designing effective anticancer treatments.

Impact:

  • Facilitates the development of novel therapeutic molecules that target specific apoptotic signaling pathways.
  • Enables the improved utilization of existing drugs by identifying synergistic combinations targeting distinct pathways.
  • Advances the field of oncology by providing a molecular basis for innovative cancer treatment strategies.

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