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Mesenteric Artery Contraction and Relaxation Studies Using Automated Wire Myography
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Left ventricular function and adrenergic hyperactivity before and after saphenous vein bypass.

H Boudoulas, R P Lewis, J S Vasko

    Circulation
    |May 1, 1976
    PubMed
    Summary

    Saphenous vein bypass surgery (SVG) impacts left ventricular performance, altering systolic time intervals (STI). Post-surgery changes, particularly shortened electromechanical systole (QS2I), suggest increased adrenergic activity, influencing cardiac function assessment.

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    08:41

    Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues

    Published on: June 3, 2019

    Area of Science:

    • Cardiology
    • Cardiac Surgery
    • Physiology

    Background:

    • Severe angina pectoris significantly impairs left ventricular function.
    • Saphenous vein bypass surgery (SVG) is a common intervention for severe angina.
    • Assessing left ventricular (LV) performance post-SVG is crucial for understanding outcomes.

    Purpose of the Study:

    • To evaluate the effect of SVG on left ventricular performance.
    • To analyze changes in systolic time intervals (STI) before and after SVG.
    • To investigate the potential causes of observed changes in LV function post-surgery.

    Main Methods:

    • Studied 40 patients with severe angina pectoris before and after SVG.
    • Measured systolic time intervals (STI), including pre-ejection period/LV ejection time (PEP/LVET) and electromechanical systole (QS2I).
    • Divided patients into two groups based on the occurrence of postoperative infarction.

    Main Results:

    • Group I (no infarction) showed a significant increase in PEP/LVET post-SVG (0.39 to 0.42).
    • Group II (with infarction) exhibited a dramatic increase in PEP/LVET post-SVG (0.33 to 0.54).
    • A marked shortening of QS2I was uniformly observed post-surgery, suggesting increased adrenergic activity.

    Conclusions:

    • SVG significantly alters left ventricular performance as assessed by STI.
    • Postoperative infarction is associated with more pronounced changes in LV function.
    • Abbreviated QS2I post-SVG may be attributed to excessive adrenergic activity and requires consideration in functional assessments.