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Related Experiment Videos

The anion gap: its use in quality control.

D L Witte, J L Rodgers, D A Barrett

    Clinical Chemistry
    |May 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    The anion gap, crucial for diagnosing acid-base disorders, was quantified across three populations. Most variability in anion gap results stems from analytical, not physiological, factors, aiding lab quality control.

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    Area of Science:

    • Clinical Chemistry
    • Internal Medicine
    • Laboratory Medicine

    Background:

    • The anion gap is a vital diagnostic tool for classifying acid-base disorders.
    • Accurate quantitative data on the anion gap is essential for clinical decision-making.

    Purpose of the Study:

    • To determine the mean and central 90% range of the anion gap in different populations.
    • To assess the contribution of analytical versus physiological variation to anion gap variability.
    • To evaluate the utility of anion gap quantitation for laboratory quality control.

    Main Methods:

    • The anion gap was calculated using the formula: sodium - (chloride + bicarbonate).
    • Three distinct populations were studied: 1047 hospitalized patients, 86 healthy volunteers, and 203 plasmapheresis donors.

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  • Means and central 90% ranges for the anion gap were determined for each group.

    • Main Results:

    • Hospitalized patients: mean anion gap of 12 mEq/liter.
    • Healthy volunteers: mean of 13 mEq/liter with a 90% range of 9-17 mEq/liter.
    • Plasmapheresis donors: mean of 11 mEq/liter with a 90% range of 7-16 mEq/liter.
    • Most observed variability in anion gap values was attributed to analytical factors rather than physiological differences.

    Conclusions:

    • Quantitation of the anion gap provides valuable interchecking of electrolyte values for laboratory quality control.
    • Abnormal anion gap values were often explained by clinical information, validating its diagnostic utility.
    • Establishing reference ranges for the anion gap aids in identifying and interpreting electrolyte abnormalities.