Continuous in vivo measurement of creatine kinase variations in man during an exercise

In order to obtain information concerning the CPK turnover during exercise, we have elaborated a technique to measure its activity continuously in vivo. A colorimetric method has been adapted to total blood. CPK was measured continuously in 5 physically fit athletes exercised on an ergometric bicycle for 30 min. There was practically no increase in enzymatic activity. The starting level was very high, corresponding perhaps to a "permanent state of enzyme release"; the exercise was not hard enough because of the fitness of the athletes or the maximal increase did not occur immediately after the exercise.