Bioinformatics in the post-sequence era
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Updated: Sep 27, 2026

A Bioinformatics Pipeline for Investigating Molecular Evolution and Gene Expression using RNA-seq
Published on: May 28, 2021
1Bioinformatics Center, Kyoto University, Uji, Kyoto 611-0011, Japan. kanehisa@kuicr.kyoto-u.ac.jp
Abstract:
In the past decade, bioinformatics has become an integral part of research and development in the biomedical sciences. Bioinformatics now has an essential role both in deciphering genomic, transcriptomic and proteomic data generated by high-throughput experimental technologies and in organizing information gathered from traditional biology. Sequence-based methods of analyzing individual genes or proteins have been elaborated and expanded, and methods have been developed for analyzing large numbers of genes or proteins simultaneously, such as in the identification of clusters of related genes and networks of interacting proteins. With the complete genome sequences for an increasing number of organisms at hand, bioinformatics is beginning to provide both conceptual bases and practical methods for detecting systemic functional behaviors of the cell and the organism.
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