Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Sublingual nitroglycerine as a tocolytic in external cephalic version: a comparative study.

Emmanuel Bujold1, Martin Sergerie, André Masse

  • 1Department of Obstetrics and Gynecology, Centre Hospitalier de l'Université de Montréal, CHUM Hôpital-St-Luc, Montréal, QC, Canada.

Journal of Obstetrics and Gynaecology Canada : JOGC = Journal D'Obstetrique Et Gynecologie Du Canada : JOGC
|March 1, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Enrichment of fetal cell-free DNA in early miscarriages for detection of aneuploidy: a novel approach.

Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC·2026
Same author

Could aspirin be both a protective factor and a factor promoting placental abruption?

Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC·2026
Same author

Temporal trends in risk of acute kidney injury among patients with preeclampsia in Canada: a retrospective cohort study.

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne·2026
Same author

Expanding First-Trimester Preterm Preeclampsia Screening With Placental Growth Factor Testing.

Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC·2026
Same author

A Comparison of Preeclampsia Screening Using Clinical Risk Factors and the Fetal Medicine Foundation Algorithm.

Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC·2026
Same author

First-Trimester Placental Growth Factor and HELLP Syndrome: The PREDICTION Study.

Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC·2026
Same journal

Excerpts from the World Medical Literature: Reproductive Endocrinology and Infertility.

Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC·2026
Same journal

Surgical site infections associated with crash cesarean sections.

Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC·2026
Same journal

Risk of Recurrent Preterm Prelabour Rupture of Membranes: Role of Mid-Trimester Cervical Length Assessment.

Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC·2026
Same journal

Family Balancing and Reproductive Autonomy: Re-Examining the Ethics of Non-Medical Sex Selection in Canada.

Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC·2026
Same journal

Iron Deficiency in Women: A Practical Illustrated Review.

Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC·2026
Same journal

The Impact of Pathogenic Variants of BRCA1, BRCA2 and Other DNA-Repair Genes on the Survival Benefits Conferred by PARP Inhibitors - Single Center Experience from Quebec.

Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC·2026
See all related articles

Sublingual nitroglycerin did not improve external cephalic version (ECV) success rates in nulliparous or parous women. While ECV success increased in parous women, it wasn't linked to nitroglycerin use, indicating a need for further research.

Area of Science:

  • Obstetrics and Gynecology
  • Perinatal Medicine
  • Pharmacology in Pregnancy

Background:

  • External cephalic version (ECV) is a procedure to turn a fetus from breech to cephalic presentation.
  • Tocolytic agents are sometimes used to relax the uterus during ECV, potentially improving success rates.
  • The efficacy of sublingual nitroglycerin as a tocolytic agent for ECV is not well-established.

Purpose of the Study:

  • To evaluate the effectiveness of sublingual nitroglycerin as a tocolytic agent in improving the success rate of external cephalic version (ECV).
  • To compare ECV success rates in nulliparous and parous women receiving nitroglycerin versus those who did not.

Main Methods:

  • Retrospective case-controlled study of 150 ECV cases after February 1998 and 137 controls before February 1998.

Related Experiment Videos

  • Comparison of ECV success rates between women receiving 0.8 mg sublingual nitroglycerin spray, those receiving no tocolytic, and a historical control group.
  • Separate analysis for nulliparous and parous women, considering parity, gestational age, maternal age, and placental location.

    • Main Results:

    • Sublingual nitroglycerin use was associated with minor side effects (hypotension, headache, nausea).
    • No significant difference in ECV success rates was observed between nitroglycerin users and non-users in nulliparous women (27% vs. 30%, p=0.86).
    • While not statistically significant in this study, parous women showed a trend towards higher success with nitroglycerin (67% vs. 51%, p=0.09), but overall success increased significantly after its introduction (71% vs. 51%, p=0.02).

    Conclusions:

    • Sublingual nitroglycerin did not demonstrate a significant benefit in improving external cephalic version success rates for nulliparous or parous women in this study.
    • The observed increase in ECV success rates in parous women after nitroglycerin introduction was not directly attributable to the agent itself.
    • Further investigation through a randomized controlled trial is recommended to definitively assess the role of sublingual nitroglycerin in ECV.