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Site-specific cleavage of human telomerase RNA using PNA-neocuproine.Zn(II) derivatives

Andrew Whitney1, Gérald Gavory, Shankar Balasubramanian

  • 1Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK CB2 1EW.

Chemical Communications (Cambridge, England)
|March 4, 2003
PubMed

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In eukaryotic DNA replication, a single-stranded DNA fragment remains at the end of a chromosome after the removal of the final primer. This section of DNA cannot be replicated in the same manner as the rest of the strand because there is no 3’ end to which the newly synthesized DNA can attach. This non-replicated fragment results in gradual loss of the chromosomal DNA during each cell duplication. Additionally, it can induce a DNA damage response by enzymes that recognize single-stranded DNA.