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[Changes in left ventricular torsion during ischemia-reperfusion]
1Fédération de cardiologie, CHU Henri Mondor, 51, av. du Malréchal de Lattre de Tassigny, 94010 Créteil, France. jgarot@free.fr
Archives Des Maladies Du Coeur Et Des Vaisseaux
|March 4, 2003
Summary
Acute myocardial ischemia significantly decreases left ventricular twist, impacting global heart function. This reduction, assessed by color tissue Doppler echocardiography, correlates with infarct size and is reversible with reperfusion.
Area of Science:
- Cardiology
- Cardiovascular Physiology
- Echocardiography
Background:
- Left ventricular (LV) twist is a crucial component of cardiac mechanics.
- Understanding LV twist alterations during ischemia-reperfusion is vital for assessing cardiac function.
Purpose of the Study:
- To characterize changes in LV twist during ischemia-reperfusion.
- To investigate the relationship between LV twist and global LV function.
Main Methods:
- LV twist was measured using color tissue Doppler echocardiography in anesthetized dogs and human patients with anterior myocardial infarction.
- Magnetic resonance myocardial tagging was used for validation in a subset of subjects.
- Measurements were taken at baseline, during ischemia, and after reperfusion.
Main Results:
- Myocardial ischemia caused a significant decrease in LV twist in both dogs and patients (p < 0.01).
- The reduction in LV twist correlated with the extent of the asynergic area and global LV function (p < 0.001).
- In dogs, LV twist improved after reperfusion compared to the ischemic phase (p < 0.01).
Conclusions:
- Acute myocardial ischemia leads to a decrease in LV twist, which is directly related to global ventricular function.
- Color tissue Doppler echocardiography offers a straightforward method for assessing LV twist in clinical settings.