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Related Experiment Videos

[Glomerular filtration markers in pediatrics].

Anne Prévot1, Stephan Martini, Jean-Pierre Guignard

  • 1Service de Pédiatrie, Unité de Néphrologie CHUV, BH 11, 1011 Lausanne. prevotanne@hotmail.com

Revue Medicale De La Suisse Romande
|March 4, 2003
PubMed
Summary

Accurately measuring glomerular filtration rate (GFR) in children is vital for diagnosing kidney disease. While inulin clearance is the gold standard, formulas like the Schwartz formula offer reliable GFR estimates when direct measurement is difficult.

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Pediatric nephrology (Berlin, Germany)·2021

Area of Science:

  • Pediatric Nephrology
  • Renal Physiology

Context:

  • Glomerular filtration rate (GFR) assessment is crucial for diagnosing and managing pediatric renal diseases.
  • Accurate GFR measurement is essential for effective patient care.

Purpose:

  • To review methods for assessing GFR in pediatric patients.
  • To highlight the accuracy of inulin clearance as the gold standard and discuss practical alternatives.

Summary:

  • Inulin clearance is the most accurate GFR measure but is cumbersome.
  • Creatinine clearance is reliable when urine is available.
  • Plasma markers like creatinine, cystatin C, and beta-2 microglobulin can estimate GFR, with formulas like the Schwartz formula being practical for children.
  • Radionuclide scans assess individual kidney function.

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Impact:

  • Provides a comprehensive overview of GFR assessment techniques in pediatric nephrology.
  • Informs clinical practice by detailing accurate and estimated GFR measurement methods.
  • Aids in the diagnosis and management of kidney diseases in children.