Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Lupus hepatitis].

Yahia Chiraz Ben Hadj1, Lilia Chaabouni, Kchir Mohamed Montacer

  • 1Service de Rhumatologie, Hôpital Charles Nicolle.

La Tunisie Medicale
|March 4, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sarcoidosis and spondyloarthritis: A coincidence or common etiopathogenesis?

Caspian journal of internal medicine·2018
Same author

[Sucess of the Corticosteroid Treatment during a Rare and Grave Inaugural Complication of the Lupus: the Acute Pancreatitis].

Therapie·2016
Same author

[Safety and Efficacy of Etanercept in Rheumatoid Arthritis With End-stage Chronic Renal Failure].

Therapie·2015
Same author

Polymorphisms of Toll-like receptor-4 and CD14 in systemic lupus erythematosus and rheumatoid arthritis.

Biomarker research·2013
Same author

[Percutaneous vertebroplasty for pain relief in patients with osteoporotic spine fractures].

La Tunisie medicale·2012
Same author

[Procedural pain assessment after spinal injections of corticosteroid].

La Tunisie medicale·2012

This case study describes a 42-year-old man with acute polyarthritis and systemic lupus erythematosus (SLE). The study links hepatic involvement, characterized by cholestasis and cytolysis, to SLE, potentially associated with anti-ribosomal P protein antibodies.

Area of Science:

  • Immunology
  • Hepatology
  • Rheumatology

Background:

  • Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with diverse clinical manifestations.
  • Hepatic involvement in SLE can present with various abnormalities, including cholestasis and cytolysis.
  • Distinguishing SLE-related liver injury from other causes is crucial for appropriate management.

Observation:

  • A 42-year-old male presented with acute polyarthritis, systemic symptoms, and immunologic disorders indicative of SLE.
  • Hepatic tests revealed cholestasis and cytolysis.
  • Hepatotoxic drugs, viral hepatitis, and other autoimmune antibodies (anti-mitochondrial, anti-smooth muscle) were excluded.

Findings:

  • Hepatic involvement was directly linked to systemic lupus erythematosus.

Related Experiment Videos

  • A correlation was observed between lupus hepatitis and the presence of autoantibodies to ribosomal P protein.
  • This specific association suggests a potential autoimmune mechanism in the liver pathology.

    • Implications:

    • The findings highlight the importance of considering lupus hepatitis in SLE patients with unexplained liver dysfunction.
    • Autoantibodies to ribosomal P protein may serve as a biomarker for hepatic involvement in SLE.
    • Further research is needed to define optimal treatment strategies for lupus hepatitis.