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Serum homocysteine level in Behçet's disease

Emel Calikoğlu1, Murat Oztaş, Neriman Sengül

  • 1Department of Dermatology, Fatih University Medical Faculty Ankara, Turkey.

Haematologia
|March 4, 2003
PubMed

Insights

This study found no significant difference in homocysteine levels between Behçet

Area of Science:

  • Rheumatology
  • Clinical Biochemistry

Background:

  • Conflicting studies exist on hyperhomocysteinemia prevalence in Behçet's disease.
  • Understanding homocysteine's role is crucial for Behçet's disease management.

Purpose of the Study:

  • To investigate serum homocysteine levels in Behçet's disease patients.
  • To compare homocysteine levels with healthy controls.

Main Methods:

  • Blood samples collected from 27 Behçet's disease patients and 21 healthy controls.
  • Serum homocysteine, vitamin B12, and folic acid measured via fluorescence polarization immunoassay and chemiluminescent enzyme immunoassay.

Main Results:

  • No significant differences observed in mean serum homocysteine levels between Behçet's disease patients and controls (p=0.05).
  • Vitamin B12 and folic acid levels also showed no significant variation between groups.

Conclusions:

  • Homocysteine levels are not elevated in Behçet's disease patients compared to controls.
  • Further research is needed on hyperhomocysteinemia in the thrombotic form of Behçet's disease.

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