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Serum homocysteine level in Behçet's disease
Emel Calikoğlu1, Murat Oztaş, Neriman Sengül
1Department of Dermatology, Fatih University Medical Faculty Ankara, Turkey.
Haematologia
|March 4, 2003
Summary
This study found no significant difference in homocysteine levels between Behçet
Area of Science:
- Rheumatology
- Clinical Biochemistry
Background:
- Conflicting studies exist on hyperhomocysteinemia prevalence in Behçet's disease.
- Understanding homocysteine's role is crucial for Behçet's disease management.
Purpose of the Study:
- To investigate serum homocysteine levels in Behçet's disease patients.
- To compare homocysteine levels with healthy controls.
Main Methods:
- Blood samples collected from 27 Behçet's disease patients and 21 healthy controls.
- Serum homocysteine, vitamin B12, and folic acid measured via fluorescence polarization immunoassay and chemiluminescent enzyme immunoassay.
Main Results:
- No significant differences observed in mean serum homocysteine levels between Behçet's disease patients and controls (p=0.05).
- Vitamin B12 and folic acid levels also showed no significant variation between groups.
Conclusions:
- Homocysteine levels are not elevated in Behçet's disease patients compared to controls.
- Further research is needed on hyperhomocysteinemia in the thrombotic form of Behçet's disease.