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High-dose verapamil + trandolapril-induced thrombotic microangiopathy
Yuksel Gokel1, Saime Paydas, Ayca Acikalin
1Department of Emergency Medicine, Faculty of Medicine, Cukurova University, Adana, Turkey. ygokel@mail.cu.edu.tr
Haematologia
|March 4, 2003
Abstract:
Thrombotic microangiopathy (TMA) is a syndrome characterized by microangiopathic haemolytic anaemia, thrombocytopenia, and several variable signs of organ damage due to the platelet thrombi in the microcirculation. This article reports a case with TMA which developed after ingestion of a high-dose combination of verapamil and trandolapril. To the authors' knowledge, no prior cases of TMA induced by trandolapril (an angiotensin-converting enzyme inhibitor) and verapamil (a calcium channel blocker) have been reported in the literature.