Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Neural stem cells in aging and disease.

T L Limke1, Mahendra S Rao

  • 1National Institute on Aging, Baltimore, MD 21224, USA. limketo@grc.nia.nih.gov

Journal of Cellular and Molecular Medicine
|March 4, 2003
PubMed
Summary

This review explores stem cell strategies for central nervous system repair, focusing on replacing cells lost in neurodegenerative diseases like Alzheimer's and Parkinson's.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Xenogeneic-free defined conditions for derivation and expansion of human embryonic stem cells with mesenchymal stem cells.

Regenerative therapy·2019
Same author

The Future State of Newborn Stem Cell Banking.

Journal of clinical medicine·2019
Same author

INDEX-db: The Indian Exome Reference Database (Phase I).

Journal of computational biology : a journal of computational molecular cell biology·2019
Same author

Repurposing the Cord Blood Bank for Haplobanking of HLA-Homozygous iPSCs and Their Usefulness to Multiple Populations.

Stem cells (Dayton, Ohio)·2018
Same author

Illustrating the potency of current Good Manufacturing Practice-compliant induced pluripotent stem cell lines as a source of multiple cell lineages using standardized protocols.

Cytotherapy·2018
Same author

Human-Induced Pluripotent Stem Cells Manufactured Using a Current Good Manufacturing Practice-Compliant Process Differentiate Into Clinically Relevant Cells From Three Germ Layers.

Frontiers in medicine·2018

Area of Science:

  • Neuroscience
  • Stem Cell Biology
  • Regenerative Medicine

Background:

  • Aging central nervous system (CNS) leads to functional decline, worsened by neurodegenerative diseases.
  • Neurodegenerative disorders like Alzheimer's and Parkinson's involve progressive loss of CNS function.
  • Current cell replacement therapies aim to restore lost neural tissue and function.

Purpose of the Study:

  • To review recent advancements in CNS stem cell biology.
  • To emphasize cellular and molecular strategies for cell replacement in neurodegenerative disorders.
  • To highlight the importance of understanding neural stem and progenitor cell interactions.

Main Methods:

  • Review of current literature on stem cell biology in the CNS.
  • Analysis of cellular and molecular approaches for cell replacement therapy.
  • Focus on strategies involving exogenous tissue transplantation and endogenous cell activation.

Main Results:

  • Exogenous tissue transplantation can replace lost CNS tissue or deliver therapeutic factors.
  • Activation of endogenous neural stem cells offers a potential regenerative approach.
  • Understanding the interplay between neural stem cells and progenitor cells is crucial for therapy success.

Conclusions:

  • Stem cell biology offers promising avenues for treating neurodegenerative diseases.
  • Cellular and molecular strategies are key to advancing CNS cell replacement therapies.
  • Further research into neural stem and progenitor cell dynamics is essential for clinical translation.

Related Experiment Videos