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An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment

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Integration from proteins to organs: the Physiome Project.

Peter J Hunter¹, Thomas K Borg

¹Bioengineering Institute, University of Auckland, New Zealand.

Nature Reviews. Molecular Cell Biology

|March 4, 2003

Summary

This summary is machine-generated.

The Physiome Project uses computational modeling to create a framework for understanding the human body. This approach integrates biological data for analyzing function and testing scientific hypotheses.

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Area of Science:

Computational biology
Systems biology
Human physiology

Background:

The human body is a complex system with intricate biochemical, biophysical, and anatomical interactions.
Existing models often lack integration across different biological scales (cells, tissues, organs).

Purpose of the Study:

To establish a comprehensive computational modeling framework for the human body.
To enable the analysis of integrative biological functions.
To develop a system for robust hypothesis testing in human physiology.

Main Methods:

Utilizing computational methods to integrate diverse biological data.
Developing multi-scale models encompassing cellular, tissue, and organ levels.
Implementing advanced data analysis techniques for biological systems.

Main Results:

A foundational framework for human body modeling is established.
The project facilitates the analysis of complex biological functions.
A system for computational hypothesis testing is provided.

Conclusions:

The Physiome Project offers a novel computational approach to understanding human physiology.
Integrated modeling enhances the analysis of biological systems.
This framework supports future research and discovery in human biology.