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ATM and related protein kinases: safeguarding genome integrity

Yosef Shiloh1

  • 1The David and Inez Myers Laboratory for Genetic Research, Department of Human Genetics and Molecular Medicine, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel. yossih@post.tau.ac.il

Nature Reviews. Cancer
|March 4, 2003
PubMed

Insights

Genome stability prevents cancer. DNA damage response pathways, like those involving ATM protein kinase, are crucial. Understanding ATM

Area of Science:

  • Genetics
  • Molecular Biology
  • Cancer Research

Background:

  • Genome stability is vital for preventing neoplasia.
  • The DNA-damage response (DDR) is a key mechanism for maintaining genome stability.
  • Defects in DDR are linked to cancer predisposition.

Purpose of the Study:

  • To elucidate the role of ATM protein kinase in the DNA-damage response.
  • To understand the link between ATM mutations, ataxia-telangiectasia (A-T), and cancer predisposition.
  • To gain insights into how defective DNA damage responses contribute to cancer development.

Main Methods:

  • Focuses on the cellular response to DNA double-strand breaks.
  • Investigates the activation and signaling pathways modulated by ATM protein kinase.
  • Examines the consequences of ATM mutations in the context of genetic disorders and cancer.

Main Results:

  • DNA double-strand breaks activate ATM protein kinase.
  • ATM kinase modulates numerous downstream signaling pathways.
  • ATM mutations cause ataxia-telangiectasia, a cancer-predisposing disorder.

Conclusions:

  • Understanding ATM's function clarifies the connection between DNA repair defects and cancer.
  • Insights into ATM signaling advance the understanding of cancer predisposition in A-T carriers.
  • Further research on ATM may lead to strategies for managing cancer risk in specific populations.

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