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Body fat mass in hemodialysis patients
Eiji Ishimura1, Senji Okuno, Taro Marukawa
1Department of Nephrology, Osaka City University Graduate School of Medicine and Shirasagi Hospital Kidney Center, Osaka, Japan. ish@med.osaka-cu.ac.jp
Background:
Changes in body fat mass in a large number of hemodialysis patients is unknown.
Methods:
Body fat mass and lean body mass were measured by dual x-ray absorptiometry (DXA) in 561 patients with hemodialysis duration less than 180 months (62.3 +/- 11.5 years old; mean +/- SD).
Results:
Fat mass tended to increase during the first 3 years of hemodialysis, and it tended to decrease thereafter. Between hemodialysis duration and the fat mass index, there was a significant positive correlation within the first 36-month period of hemodialysis (r = 0.124; P < 0.05; n = 245), and a significant negative correlation during the period of 36 to 180 months. (r = -0.192; P < 0.001; n = 316). There was no tendency of change in the lean body mass index.
Conclusion:
Considering the results together with the authors previous prospective study results, which show significant fat mass increase in the first year of hemodialysis, the present cross-sectional study may suggest that fat mass gradually increases in the first 3 years and decreases thereafter. Fat mass is suggested to be a nutritional parameter in hemodialysis patients.