Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The function of neuropilin/plexin complexes.

Andreas W Püschel1

  • 1Institut für Allgemeine Zoologie und Genetik, Westfälische Wilhelms-Universität, Schlossplatz 5, D-48149 Münster Germany. apuschel@uni-muenster.de

Advances in Experimental Medicine and Biology
|March 5, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pip5k1γ regulates axon formation by limiting Rap1 activity.

Life science alliance·2024
Same author

Editorial Expression of Concern: Class 3 semaphorins control vascular morphogenesis by inhibiting integrin function.

Nature·2024
Same author

An isoform-specific function of Cdc42 in regulating mammalian Exo70 during axon formation.

Life science alliance·2022
Same author

Author Correction: Membrane-binding and activation of LKB1 by phosphatidic acid is essential for development and tumour suppression.

Nature communications·2022
Same author

The balance of mitochondrial fission and fusion in cortical axons depends on the kinases SadA and SadB.

Cell reports·2021
Same author

On the role of vesicle transport in neurite growth: Modeling and experiments.

Mathematical biosciences·2021

Neuropilins bind semaphorins, but plexins are required for signal transduction. This receptor complex mediates semaphorin-induced cytoskeletal collapse via Rho-like GTPases.

Area of Science:

  • Cellular and Molecular Biology
  • Neuroscience
  • Biochemistry

Background:

  • Neuropilins are known to bind class 3 semaphorins.
  • Plexins are essential for semaphorin-mediated signaling.
  • The precise roles of neuropilins and plexins in receptor formation were unclear.

Purpose of the Study:

  • To elucidate the functional roles of neuropilins and plexins in semaphorin receptor complex formation.
  • To understand the mechanism of downstream signal transduction initiated by semaphorins.

Main Methods:

  • Biochemical assays to study protein-protein interactions.
  • Cell-based assays to analyze cytoskeletal dynamics.
  • Analysis of conserved domains within the plexin family.

Related Experiment Videos

Main Results:

  • Neuropilins function as the ligand-binding component of the receptor complex.
  • Plexins serve as the signal-transducing subunit, mediating cytoskeletal collapse.
  • The conserved cytoplasmic domain of plexins interacts with Rho-like GTPases.

Conclusions:

  • Neuropilin-plexin complexes form functional semaphorin receptors.
  • Semaphorin signaling, through this complex, regulates cytoskeletal organization.
  • Rho-like GTPases are key effectors in semaphorin-induced cellular responses.