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Related Experiment Videos

Transmembrane adapters: attractants for cytoplasmic effectors.

Jonathan A Lindquist1, Luca Simeoni, Burkhart Schraven

  • 1Institute of Immunology, Otto-von-Guericke University, Magdeburg, Germany.

Immunological Reviews
|March 5, 2003
PubMed
Summary

Transmembrane adapter proteins (TRAPs) are crucial signaling scaffolds near immunoreceptors. These proteins coordinate cellular responses by recruiting other proteins through tyrosine phosphorylation.

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Area of Science:

  • Immunology
  • Cell Biology
  • Molecular Biology

Background:

  • Transmembrane adapter proteins (TRAPs) are a growing family of signaling molecules.
  • Key TRAPs include LAT, PAG/Cbp, SIT, TRIM, NTAL, and pp30.
  • TRAPs possess multiple tyrosine phosphorylation sites, enabling protein recruitment.

Purpose of the Study:

  • To introduce the family of Transmembrane adapter proteins (TRAPs).
  • To highlight the structural and functional characteristics of TRAPs.
  • To explain the role of TRAPs in immune signaling pathways.

Main Methods:

  • Literature review of TRAP family proteins.
  • Analysis of structural features and phosphorylation sites.
  • Functional role in immune receptor signaling.

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Main Results:

  • TRAPs act as scaffolds, recruiting cytosolic adapter and effector proteins.
  • Their membrane localization facilitates proximity to immunoreceptors.
  • TRAPs modulate signals received from immunoreceptors.

Conclusions:

  • TRAPs are essential for coordinating and modulating cellular responses.
  • Their function is critical in immune signaling.
  • TRAPs represent key nodes in signal transduction pathways.