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Updated: Sep 27, 2026

Development of a Nose-only Inhalation Toxicity Test Chamber That Provides Four Exposure Concentrations of Nano-sized Particles
05:07

Development of a Nose-only Inhalation Toxicity Test Chamber That Provides Four Exposure Concentrations of Nano-sized Particles

Published on: March 18, 2019

Developmental toxicity of N-methyl-2-pyrrolidone in rats following inhalation exposure

A M Saillenfait1, F Gallissot, G Morel

  • 1Institut National de Recherche et de Sécurité, Avenue de Bourgogne, BP No 27, 54501 Vandoeuvre, France. anne-marie.saillenfait@inrs.fr

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
|March 5, 2003
PubMed

The developmental toxicity of inhaled N-methyl-2-pyrrolidone (NMP) was studied in Sprague-Dawley rats. Pregnant rats were exposed whole body to NMP vapours at concentrations of 0, 30, 60 and 120 ppm, 6 h/day, on gestational days (GD) 6 through 20. Maternal body weight gain was significantly decreased at 60 and 120 ppm on GD 6-13 and maternal food consumption was reduced at 120 ppm on GD 13-21. No significant difference in the gestational weight change corrected for the weight of the gravid uterus was observed, whatever NMP concentration. There were no adverse effects on embryo/fetal viability or evidence of teratogenicity at any concentration tested. Fetal toxicity indicated by reduced fetal weight was observed at 120 ppm. Thus, the no-observed-adverse-effect level (NOAEL) for maternal and developmental toxicity was 30 and 60 ppm, respectively.

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