Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cytokine-induced sickness behavior.

Keith W Kelley1, Rose-Marie Bluthé, Robert Dantzer

  • 1Department of Animal Sciences, Laboratory of Immunophysiology, University of Illinois, 207 Edward R. Madigan Laboratory, 1201 West Gregory Drive, Urbana 61801, USA. kwkelley@uiuc.edu

Brain, Behavior, and Immunity
|March 5, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genome-wide identification, classification, and expression pattern analysis of the TCP transcription factor family in carrot.

Frontiers in plant science·2026
Same author

Molecular analysis of immune cell subsets and cytokine profiles in septic Vietnamese patients.

Clinical and experimental medicine·2025
Same author

Correction: B-mode ultrasound and contrast-enhanced ultrasound-based radiomics interpretable analysis for the prediction of macrotrabecular-massive subtype of hepatocellular carcinoma.

The ultrasound journal·2025
Same author

Effectiveness and safety of acupuncture for Parkinson's disease anxiety: a systematic review and meta-analysis.

Frontiers in aging neuroscience·2025
Same author

B-mode ultrasound and contrast-enhanced ultrasound-based radiomics interpretable analysis for the prediction of macrotrabecular-massive subtype of hepatocellular carcinoma.

The ultrasound journal·2025
Same author

Evolutionary paradigm of distinct viral coding regions of BVDV associated with different nucleotide usage patterns.

BMC veterinary research·2025
Same journal

Microglial brain-derived neurotrophic factor (BDNF) supports the behavioral and synaptogenic effects of ketamine.

Brain, behavior, and immunity·2026
Same journal

Hippocampal C5a-C5aR1 axis drives age-related memory decline via collapsing synaptic chloride homeostasis.

Brain, behavior, and immunity·2026
Same journal

Bifidobacterium bifidum TMC3115-RAW264.7 cell conditioned mediums promote the synaptic development of primary hippocampal neuron via activating IL-6/JAK2/STAT3 signaling pathway.

Brain, behavior, and immunity·2026
Same journal

T cells contribute to approaching positive but potentially risky stimuli through medial prefrontal cortex immune modulation.

Brain, behavior, and immunity·2026
Same journal

Insulin modulates mPFC gene expression and emotional behavior in a sex-specific manner following fetal growth restriction.

Brain, behavior, and immunity·2026
Same journal

Activation of the cGAS-STING pathway contributes to cancer-related fatigue in a murine model of head and neck cancer.

Brain, behavior, and immunity·2026
See all related articles

Infection triggers sickness behaviors, like fatigue and loss of appetite, driven by brain inflammation. Understanding these cytokine-induced changes is key to improving cancer patient recovery and quality of life.

Area of Science:

  • Psychoneuroimmunology
  • Neuroscience
  • Oncology

Background:

  • Infections induce profound behavioral changes in humans and animals, including fatigue, appetite loss, and social withdrawal.
  • These sickness behaviors are mediated by proinflammatory cytokines acting within the brain.
  • In cancer patients, exaggerated sickness symptoms like cachexia can be life-threatening and severely impair quality of life.

Purpose of the Study:

  • To explore the role of proinflammatory cytokines in mediating sickness behaviors.
  • To investigate the communication pathways between cytokine and neurotransmitter receptors.
  • To identify potential clinical applications for alleviating sickness symptoms in cancer patients.

Main Methods:

  • Review of psychoneuroimmunology research defining cytokine roles in sickness behavior.

Related Experiment Videos

  • Analysis of existing literature on cytokine-neurotransmitter receptor interactions.
  • Discussion of potential translation of basic research findings to clinical settings.

    • Main Results:

    • Proinflammatory cytokines are central mediators of sickness behaviors.
    • Sickness behaviors represent a central motivational state promoting recovery.
    • Significant impairment in quality of life often precedes severe debilitation in cancer patients.

    Conclusions:

    • Further understanding of cytokine and neurotransmitter receptor communication is crucial.
    • Clinical studies are needed to translate findings into treatments for sickness symptoms.
    • Alleviating sickness symptoms can improve quality of life for cancer patients.