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Low dose amiodarone causing pseudo-alcoholic cirrhosis.

Amitalh Singhal1, Partha Ghosh, Shahid Anis Khan

  • 1Department of Elderly Care, Lister Hospital, Corey's Mill Lane, Stevenage, Hertfordshire SG1 4AB, UK.

Age and Ageing
|March 5, 2003
PubMed
Summary

Low-dose amiodarone (an anti-arrhythmic drug) can cause rare, severe liver damage, including cirrhosis, even in elderly patients. This case highlights the potential for serious hepatic toxicity with amiodarone, regardless of dosage.

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Area of Science:

  • Cardiology
  • Hepatology
  • Pharmacology

Background:

  • Amiodarone is a widely prescribed anti-arrhythmic medication, particularly in elderly populations.
  • While abnormal liver function is a known side effect, clinically significant liver disease is uncommon.
  • Reported hepatic issues include hepatomegaly, cholestasis, acute hepatitis, and rare cases of liver failure.

Observation:

  • This report details an unusual case of a patient developing cirrhosis.
  • The patient was on a low dose of amiodarone.
  • The presentation mimicked alcoholic cirrhosis.

Findings:

  • Severe hepatic toxicity, specifically cirrhosis, associated with low-dose amiodarone is exceedingly rare.
  • This presentation has not been previously documented in English-language medical literature.

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  • The patient's condition suggests amiodarone-induced liver injury.

    • Implications:

    • Clinicians should consider amiodarone toxicity in patients with unexplained cirrhosis, even on low doses.
    • This case underscores the importance of monitoring liver function in patients taking amiodarone long-term.
    • Further research may be needed to understand the mechanisms of amiodarone-induced liver injury at lower doses.