Related Experiment Videos
Warfarin sensitivity: be aware of genetic influence
Tayyaba Khan1, Farhad Kamali, Ann Daly
1Department of Pharmacological Sciences, University of Newcastle upon Tyne, Newcastle Upon Tyne NE1 4LP, UK.
Age and Ageing
|March 5, 2003
Abstract
Background:
avoidance of over anticoagulation in response to warfarin therapy would reduce risk of associated bleeding.
Subjects:
two elderly patients with venous thromboembolism exhibited extreme anticoagulant response to warfarin. Both were noted to have variant CYP2C9 alleles, which reduce the metabolic capacity of cytochrome P450 2C9.
Discussion:
adverse outcomes with warfarin therapy could be explained and possibly avoided by identifying patients with variant alleles for CYP2C9 before initiation of therapy.