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Updated: Aug 1, 2026

Application of Mouse Parthenogenetic Haploid Embryonic Stem Cells as a Substitute of Sperm
Published on: November 19, 2020
Reproductive semi-cloning respecting biparental origin. A biologically unsound principle
H Tateno1, K E Latham, R Yanagimachi
1Department of Biological Sciences, Asahikawa Medical College, Asahikawa, Japan.
Abstract:
The original debate article proposed the use of "semi-cloning" as a viable method for assisted reproduction. This debate counters the proposal as being biologically unsound. Given the fundamental limitations of chromosomal segregation and genomic imprinting, the notion of using the MII oocyte to drive haploidization of a somatic cell genome and thereby obtain a substitute for authentic gametes is ill-conceived and untenable.
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