Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Subfertility reflects accelerated ovarian ageing.

Helen S Kok1, Kristel M van Asselt, Yvonne T van der Schouw

  • 1Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, HP nr Str 6.131, Heidelberglaan 100, 3585 CX Utrecht, The Netherlands. H.S.Kok@jc.azu.nl

Human Reproduction (Oxford, England)
|March 5, 2003
PubMed
Summary

Accelerated ovarian aging is linked to subfertility and early menopause. Later menopause reduces risks of menstrual irregularity, fertility issues, and miscarriage, supporting the link between ovarian aging and reproductive health.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Completeness and accuracy of data transfer of routine maternal health services data in the greater Accra region.

BMC research notes·2015
Same author

Pragmatic randomized trials in drug development pose new ethical questions: a systematic review.

Drug discovery today·2015
Same author

Polysaccharide conjugate vaccine against pneumococcal pneumonia in adults.

The New England journal of medicine·2015
Same author

Common carotid intima-media thickness relates to cardiovascular events in adults aged <45 years.

Hypertension (Dallas, Tex. : 1979)·2015
Same author

A novel approach for establishing cardiovascular drug efficacy.

Nature reviews. Drug discovery·2014
Same author

Cardiovascular manifestations of HIV infection in children.

European journal of preventive cardiology·2014

Area of Science:

  • Reproductive Endocrinology
  • Ovarian Physiology
  • Human Reproduction

Background:

  • Accelerated ovarian aging may contribute to subfertility and early menopause.
  • Understanding this link is crucial for reproductive health.
  • The study investigates the relationship between ovarian aging markers and fertility outcomes.

Purpose of the Study:

  • To determine the extent to which accelerated ovarian aging leads to subfertility.
  • To explore the association between accelerated ovarian aging and early menopause.
  • To identify specific indicators of ovarian aging and their impact on reproductive life.

Main Methods:

  • Logistic regression analysis of 2393 women who never used hormonal contraceptives or IUDs.
  • Age at menopause used as a proxy for accelerated ovarian aging.

Related Experiment Videos

  • Menstrual cycle irregularity, fertility consultations, parity, and miscarriage history assessed as measures of ovarian aging and subfertility.

    • Main Results:

    • Later menopause onset (by 5 years) significantly reduced the odds of menstrual irregularity (OR=0.74) and fertility consultations (OR=0.82).
    • Delayed menopause also decreased the likelihood of nulliparity (OR=0.78) and uniparity (OR=0.78), and reduced the probability of long intervals between births (OR=0.73).
    • A trend towards reduced miscarriage probability was observed (OR=0.89).

    Conclusions:

    • Fertility problems are often precursors to early menopause.
    • The findings suggest that both subfertility and early menopause are manifestations of accelerated ovarian aging.
    • This supports a unified view of ovarian aging impacting reproductive lifespan.