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Coagulopathies and arterial stroke.

Mark L Moster1

  • 1Department of Neurosensory Sciences, Albert Einstein Medical Center, Philadelphia, USA. mmoster@aol.com

Journal of Neuro-Ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society
|March 5, 2003
PubMed
Summary

Hypercoagulable states, often linked to venous clots, can also cause arterial thrombosis. Several genetic and acquired conditions, including protein deficiencies and specific mutations, are associated with this risk.

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Area of Science:

  • Hematology
  • Vascular Medicine
  • Genetics

Background:

  • Hypercoagulable states are typically associated with venous thromboembolism.
  • Arterial thrombosis is a less common but significant manifestation.

Purpose of the Study:

  • To review the conditions associated with arterial thrombosis in the context of hypercoagulable states.

Main Methods:

  • Literature review of studies reporting arterial thrombosis in various hypercoagulable conditions.

Main Results:

  • Arterial thromboses are documented in deficiencies of protein S, protein C, and antithrombin III.
  • Factor V Leiden and prothrombin gene mutations are linked to arterial clot formation.
  • Other implicated conditions include hyperhomocysteinemia, dysfibrinogenemia, plasminogen deficiency, sickle cell disease, and antiphospholipid antibody syndrome.

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Conclusions:

  • Various inherited and acquired hypercoagulable states can manifest as arterial thrombosis.
  • Recognition of these conditions is crucial for appropriate patient management and prevention strategies.