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Olanzapine treatment of anorexia nervosa: a retrospective study
Amanda Malina1, Jill Gaskill, Claire McConaha
1Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA.
Background:
Recent reports raise the possibility that olanzapine, which commonly causes weight gain in non-eating-disordered subjects, assisted weight gain and mood during refeeding in anorexia nervosa (AN) patients.
Methods:
Eighteen AN subjects who engaged in open treatment with olanzapine were retrospectively questioned about their response.
Results:
Subjects reported a significant reduction in anxiety, difficulty eating, and core eating disorder symptoms after taking olanzapine.
Discussion:
These data lend support to the possibility that olanzapine may be useful in AN patients.
Conclusion:
A controlled trial is necessary to prove that olanzapine is efficacious.