Related Experiment Video

Updated: Sep 27, 2026

Measuring DNA Damage and Repair in Mouse Splenocytes After Chronic In Vivo Exposure to Very Low Doses of Beta- and Gamma-Radiation
11:24

Measuring DNA Damage and Repair in Mouse Splenocytes After Chronic In Vivo Exposure to Very Low Doses of Beta- and Gamma-Radiation

Published on: July 3, 2015

Induction of DNA damage in human lymphocytes treated with a soluble factor secreted by Taenia solium metacestodes

Luis A Herrera1, Patricia Tato, José L Molinari

  • 1Instituto de Investigaciones Biomédicas, UNAM, Ciudad Universitaria, México D.F., México. metil@hotmail.com

Teratogenesis, Carcinogenesis, and Mutagenesis
|March 5, 2003
PubMed

Insights

A Taenia solium factor (MF) shows genotoxicity in human cells, increasing micronuclei frequency. This DNA instability suggests a potential risk for malignant transformation, warranting further investigation in human exposure contexts.

Area of Science:

  • Parasitology
  • Genetics
  • Cell Biology

Background:

  • Taenia solium metacestode (MF) previously demonstrated cell transformation capabilities.
  • Genotoxicity assessment of MF is crucial due to its potential health implications.

Purpose of the Study:

  • To evaluate the genotoxic effects of MF on cultured human lymphocytes.
  • To assess DNA instability induced by MF using the micronucleus assay.

Main Methods:

  • Cultured human lymphocytes were treated with MF.
  • The micronucleus assay was employed to detect chromosomal damage.

Main Results:

  • A significant increase in micronucleated cells was observed in MF-treated lymphocyte cultures.
  • MF exposure induced notable DNA instability in human lymphocytes.

Conclusions:

  • MF exhibits genotoxic potential in human lymphocytes.
  • The DNA-damaging effects of MF suggest a possible risk for malignant transformation.
  • Further research is needed to confirm MF secretion by T. solium in humans and associated risks.

More Related Videos

Isolating Lymphocytes from the Mouse Small Intestinal Immune System11:28

Isolating Lymphocytes from the Mouse Small Intestinal Immune System

Published on: February 28, 2018

A Strategy for the Study of IL-9-Producing Lymphoid Cells in the Nippostrongylus brasiliensis Infection Model08:38

A Strategy for the Study of IL-9-Producing Lymphoid Cells in the Nippostrongylus brasiliensis Infection Model

Published on: March 3, 2023

Related Concept Videos

Amebiasis01:28

Amebiasis

Entamoeba histolytica, a protozoan parasite, is responsible for intestinal and extraintestinal amebiasis. Though a significant proportion of infections remain asymptomatic, approximately 50 million individuals annually are estimated to present with clinical disease, resulting in up to 100,000 deaths globally. The disease burden is disproportionately high in regions with lower socioeconomic status, such as parts of India, Africa, Mexico, and Latin America.Etiology and TransmissionThe infective...