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Multiple sclerosis: report on 200 cases from Iran.

Hossein Kalanie1, Kurosh Gharagozli, Amir Reza Kalanie

  • 1Shahid Beheshtie University of Medical Sciences, Department of Neurology, Loghman Hospital, Kamalie Street, Tehran, Iran.

Multiple Sclerosis (Houndmills, Basingstoke, England)
|March 6, 2003
PubMed
Summary
This summary is machine-generated.

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This study reviewed 200 Iranian patients with multiple sclerosis (MS), finding the relapsing-remitting course most common. Most patients presented with pyramidal system involvement, and the mean age of onset was 27 years.

Area of Science:

  • Neurology
  • Clinical Neuroscience
  • Epidemiology

Background:

  • Multiple Sclerosis (MS) is a chronic neurological disease.
  • Understanding the clinical characteristics of MS in diverse populations is crucial for effective management.
  • Previous studies have highlighted variations in MS presentation and progression globally.

Purpose of the Study:

  • To analyze the clinical findings and disease course of 200 definite multiple sclerosis patients in Iran.
  • To determine the demographic and clinical characteristics of MS in this specific cohort.
  • To identify common modes of presentation and factors associated with benign MS.

Main Methods:

  • Retrospective review of clinical data from 200 patients diagnosed with definite multiple sclerosis.

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  • Inclusion criteria included Poser et al.'s diagnostic criteria and positive MRI findings.
  • Data collected encompassed clinical course, age of onset, gender, mode of presentation, family history, and disability status.

    • Main Results:

    • The majority of patients (88%) exhibited a relapsing-remitting (RR) clinical course.
    • The mean age of onset for the entire group was 27 +/- 7.4 years.
    • Pyramidal system involvement was the most frequent initial presentation, and the female-to-male ratio was 2.5:1.

    Conclusions:

    • The relapsing-remitting course is predominant in Iranian MS patients.
    • Pyramidal symptoms are a common initial manifestation of MS in this population.
    • A significant proportion of patients experienced benign multiple sclerosis, indicating a favorable prognosis for some.