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Related Experiment Videos

Screening for multiple sclerosis cognitive impairment using a self-administered 15-item questionnaire.

R H B Benedict1, F Munschauer, R Linn

  • 1Department of Neurology, State University of New York (SUNY) at Buffalo School of Medicine, Buffalo, New York, USA. benedict@buffalo.edu

Multiple Sclerosis (Houndmills, Basingstoke, England)
|March 6, 2003
PubMed
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A new MS Neuropsychological Screening Questionnaire (MSNQ) effectively screens for cognitive impairment in multiple sclerosis patients. The informant-report form shows high accuracy in identifying neuropsychological deficits.

Area of Science:

  • Neuroscience
  • Clinical Psychology
  • Neurology

Background:

  • Multiple sclerosis (MS) often causes neuropsychological impairment.
  • Current screening methods are time-consuming and require expert interpretation.
  • There is a need for cost-effective and efficient screening tools for MS-related cognitive issues.

Purpose of the Study:

  • To develop and validate a brief, self-administered screening questionnaire for neuropsychological impairment in MS patients.
  • To assess the reliability and accuracy of the MS Neuropsychological Screening Questionnaire (MSNQ).

Main Methods:

  • Generated 80 items, reduced to 15 via Rasch analysis to create the MSNQ (patient and informant forms).
  • Administered the MSNQ and a comprehensive neuropsychological test battery to 50 MS patients and their caregivers.

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  • Analyzed reliability (Cronbach's alpha) and correlations between MSNQ scores and objective cognitive tests.

    • Main Results:

    • MSNQ demonstrated high reliability (Cronbach's alpha 0.93-0.94).
    • The informant form correlated with objective cognitive performance (processing speed, memory) and not depression.
    • A cut-off score of 27 on the informant form achieved 83% sensitivity and 97% specificity.

    Conclusions:

    • The self-administered MSNQ is a reliable tool for screening neuropsychological impairment in MS.
    • The informant-report form accurately predicts cognitive deficits in MS patients.
    • The MSNQ offers a cost-effective and efficient alternative to traditional neuropsychological testing.