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Relationship between serum N-carbamoyl-beta-D-glucopyranosylamine level and renal failure
Tetsuro Hamafuji1, Wakako Tsugawa, Koji Sode
1Department of Biotechnology, Faculty of Technology, Tokyo University of Agriculture and Technology, Koganei, Tokyo, Japan. hamafuji@irc-net.co.jp
Abstract:
A statistical investigation was carried out on the distribution of serum N-carbamoyl-beta-D-glucopyranosylamine (NCG) among various patient groups. The serum NCG levels of patients treated in the departments of hemodialysis (131 +/- microM), nephritic syndrome (47 +/- 54 microM), and diabetes mellitus (55 +/- 70 microM) were significantly higher (p < 0.01) than those in other internal disease patients (18 +/- 22 microM) and healthy volunteers (6 +/- 22 microM). The serum NCG level was greatly reduced by hemodialysis therapy, however a return to initial NCG levels was observed within about one week. These results indicate that a high serum NCG level is a feature of renal failure patients, and a relationship was demonstrated between hyperuremia and NCG formation and accumulation in blood.
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