Extra-renal erythropoietin secretion after bilateral nephrectomy
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Updated: Aug 29, 2026

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
Published on: July 3, 2013
Takeshi Nakanishi1, Seizaburo Horikawa, Keisuke Hiraoka
1Department of Kidney and Dialysis, Hyogo College of Medicine, Mukogawa-cho, Nishinomiya, Japan. t-nkns@hyo-med.ac.jp
Abstract:
Serum concentrations of erythropoietin and soluble transferrin receptor were examined immediately after removal of the remaining kidney in a patient with a history of unilateral radical nephrectomy. Unexpectedly, the erythropoietin concentration increased from 18.2 U/L to 42.5 within 6 h after the operation. Soluble transferrin receptor (TfR) concentration rapidly decreased from 2,725 microgram/L to 1,548 during the 12-h postoperative period. Extra-renal erythropoietin secretion could increase to more than twice as much as the renal secretion of erythropoietin immediately after the loss of renal tissue, and the rise in erythropoietin could accelerate the recycling of TfR, thus causing a decrease in its serum concentration.
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