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Updated: Sep 27, 2026

Structure-Guided Design and Development of Novel Cyclophilin A Inhibitors and Ganoderiol-F Derivatives: An In-Silico Approach
Published on: June 23, 2026
Design and synthesis of bicyclic pyrimidinone-based HCV NS3 protease inhibitors
Peter W Glunz1, Brent D Douty, Carl P Decicco
1Bristol-Myers Squibb Pharmaceutical Research Institute, PO Box 5400, Princeton, NJ 08543-5400, USA. peter.glunz@bms.com
Abstract:
A series of bicyclic pyrimidinone-based HCV NS3 protease inhibitors was synthesized via selective C8 position functionalization. Substituted phenylamides and phenylureas were preferred in the S2 binding pocket.
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