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Interaction of binuclear xylylthiolato(2,2',2"-terpyridine)platinum(II) complexes with DNA
Hiromasa Kurosaki1, Naoki Yamakawa, Masamitsu Sumimoto
1Faculty of Pharmaceutical Sciences, Kumamoto University, Oe-honmachi 5-1, Kumamoto 862-0973, Japan.
Bioorganic & Medicinal Chemistry Letters
|March 6, 2003
Abstract:
The new binuclear platinum(II) complexes, (1,3-benzenedimethanethiolate-S)di(2,2',2"-terpyridine)diplatinum(II) chloride tetrahydrate, 5, and (1,4-benzenedimethanethiolate-S)di(2,2',2"-terpyridine)diplatinum(II) chloride tetrahydrate, 6, were synthesized in order to investigate the binding of platinum(II) complex with calf thymus DNA, which was examined by UV and CD spectroscopies. Complex 5 interacted strongly with DNA by intercalation compared to 6.