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Bis(acridinylthiourea)platinum(II) complexes: synthesis, DNA affinity, and biological activity in glioblastoma cells
Todd M Augustus1, Joel Anderson, Suzanne M Hess
1Department of Chemistry, Wake Forest University, Winston-Salem, NC 27109, USA.
Bioorganic & Medicinal Chemistry Letters
|March 6, 2003
Abstract:
The preparation of two novel bis(acridine)platinum(II) complexes is reported. The 4+ charged conjugates associate strongly with double-stranded native DNA (K(i)>10(6)), possibly through bisintercalation. A cell viability assay was used to demonstrate that both compounds are capable of mediating cytotoxicity at micromolar concentrations in SNB19 brain tumor cells.