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Updated: Sep 27, 2026

Synthesis of Masarimycin, a Small Molecule Inhibitor of Gram-Positive Bacterial Growth
Published on: January 7, 2022
Discovery of the first antibacterial small molecule inhibitors of MurB
Joanne J Bronson1, Kenneth L DenBleyker, Paul J Falk
1Bristol-Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, Wallingford, CT 06492, USA.
Abstract:
A series of imidazolinone analogues was synthesized and shown to possess potent MurB inhibitory as well as good antibacterial activity.
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