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Related Experiment Videos

Artificial polymeric cells for targeted drug delivery.

A Omolola Eniola1, Daniel A Hammer

  • 1Department of Chemical Engineering and Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA 19104-6316, USA.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|March 6, 2003
PubMed
Summary

This study developed a biodegradable drug delivery system using Poly(lactic-co-glycolic acid) microspheres coated with sialyl Lewis(x) to target inflammation sites. The system mimics leukocyte adhesion, offering a novel approach for anti-inflammatory drug delivery.

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Area of Science:

  • Biomaterials Science
  • Drug Delivery Systems
  • Immunology

Background:

  • Selectins are key molecules in disease-related inflammation due to their specific expression and interactions.
  • Targeted delivery of anti-inflammatory drugs remains a challenge in treating chronic inflammatory conditions.

Purpose of the Study:

  • To develop a biodegradable drug delivery vehicle using Poly(lactic-co-glycolic acid) (PLGA) microspheres.
  • To functionalize PLGA microspheres with selectin-ligand chemistry for targeted delivery to inflammation sites.
  • To mimic leukocyte adhesion properties for enhanced drug targeting.

Main Methods:

  • PLGA microspheres were synthesized and functionalized with biotinylated-sialyl Lewis(x) (sLe(x)) via avidin linkage.
  • The adhesive behavior of the sLe(x)-coated microspheres was evaluated using flow chambers, mimicking leukocyte rolling on selectins.

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  • Rolling velocity and residence time were modulated by adjusting sLe(x) density on the microsphere surface.

    • Main Results:

    • The sLe(x)-coated PLGA microspheres successfully mimicked the adhesive behavior of leukocytes.
    • These artificial leukocytes exhibited slow rolling on selectin-coated surfaces, comparable to actual leukocytes.
    • The rolling velocity and residence time could be controlled by varying the density of sLe(x) on the microspheres.

    Conclusions:

    • A biodegradable, targeted drug delivery vehicle was successfully developed.
    • The system effectively mimics leukocyte adhesion properties, offering potential for targeted anti-inflammatory drug delivery.
    • The ability to tune adhesive properties provides a versatile platform for drug delivery applications in chronic inflammation.