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Nanotechnological approaches for the delivery of macromolecules
Daan J A Crommelin1, Gert Storm, Wim Jiskoot
1Department Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, PO Box 80082, Utrecht 3508 TB, The Netherlands. d.j.a.crommelin@pharm.uu.nl
Abstract:
In this overview, novel approaches are described for the controlled release and/or for the targeted delivery of macromolecules such as proteins and DNA. The building stones of these highly complex systems are (phospho)lipids and/or (biodegradable) polymers. They should be carefully chosen and preparation protocols should be rationally designed to maximize chances for success.