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Mammalian fatty acid synthase: closure on a textbook mechanism?
Peter Leadlay1, Abel Baerga-Ortiz
1Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, United Kingdom.
Chemistry & Biology
|March 6, 2003
Abstract:
Mammalian fatty acid synthase is a classic example of a chain-building multienzyme. A cornerstone of its mechanism has been the obligatory collaboration of two identical subunits, with fatty acyl intermediates transferring between them. Now, fresh evidence has upset this view.