Related Experiment Video
Updated: Aug 3, 2026
A Versatile, Behavioral Method to Investigate Thyroid Hormone Effects on Cerebellar Function
Published on: October 6, 2023
A multicenter cluster randomized controlled trial of strategies to improve thyroid function testing
Valentin Daucourt1, Florence Saillour-Glénisson, Philippe Michel
1Comité de Coordination pour l'Evaluation Clinique et la Qualité en Aquitaine, Hôpital Xavier Arnozan, Pessac, France. valentin.daucourt@ccecqa.asso.fr
Objectives:
This project aimed to compare the independent and combined effectiveness of two implementation interventions of guidelines for ordering thyroid function tests: a Memorandum Pocket Card (MPC) and a Test Request Form (TRF).
Research Design:
Intervention groups were wards. The study used an experimental 2*2 factorial design with matching hospitals according to size and activity and wards according to preintervention appropriateness for test ordering. Four ward groups were established: the dual intervention group, the order form group, the pocket card group and the control group. Physicians in all groups received guidelines and were invited to a local information meeting.
Measures:
The main outcome measure of effectiveness was the Guideline Conformity Rate (GCR).
Results:
Six hospitals participated in the study (two middle-sized hospitals, two small-sized hospitals and two psychiatric hospitals). A total of 1412 orders for thyroid function tests were collected. GCR was 78% in the dual intervention group, 83% in the order form group, 73% in the pocket card group and 62% in the control group. The interaction between TRF and MPC was not significant (beta = -0.70; P = 0.21). Compared with simple information, TRF was effective in increasing GCR (OR, 2.65; 95% CI, 1.52-4.62), unlike MPC (OR, 1.28; CI, 0.75-2.19).
Conclusions:
Using a robust design, our study shows the greater effectiveness of TRF than MPC and their association in implementing thyroid function test guidelines.
