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Related Experiment Videos

The UMD-p53 database: new mutations and analysis tools.

Christophe Béroud1, Thierry Soussi

  • 1Laboratoire de Génétique Moléculaire, CHU de Montpellier, Institut Universitaire de Recherche Clinique, Montpellier Cedex, France. Christophe.Beroud@igh.cnrs.fr

Human Mutation
|March 6, 2003
PubMed
Summary

The UMD-p53 database now offers enhanced tools for analyzing tumor suppressor gene TP53 (p53) mutations. These updates aid molecular epidemiology, pharmacogenetics, and patient-based cancer studies.

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Area of Science:

  • Oncology
  • Genetics
  • Bioinformatics

Background:

  • The TP53 (p53) tumor suppressor gene is frequently mutated in human cancers, with over 14,971 mutations reported in 150 cancer types.
  • Existing data on TP53 mutations are vast, necessitating specialized tools for comprehensive analysis.

Purpose of the Study:

  • To describe recent developments and improvements to the UMD-p53 locus-specific mutation database.
  • To enhance the database's utility for analyzing TP53 gene mutations in various cancer research contexts.

Main Methods:

  • Development and integration of new fields and automated routines within the UMD-p53 database software.
  • Implementation of modules for splice site analysis, prescreening, UV impact, and cancer distribution.
  • Establishment of a data validation procedure to ensure high-quality curated data.

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Main Results:

  • The UMD-p53 database now includes automated analysis of splice sites, providing insights into silent mutations.
  • New modules facilitate prescreening, UV-related mutation analysis, and distribution patterns across cancer types.
  • Enhanced data validation ensures the reliability of compiled somatic and germline TP53 mutations and polymorphisms.

Conclusions:

  • Recent advancements in the UMD-p53 database provide powerful tools for researchers.
  • The improved database supports molecular epidemiology, pharmacogenetics, and patient-specific cancer studies involving TP53 mutations.