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Sclerosing hemangioma with lymph node metastasis.
Kyung-Hee Kim1, Hae-Joung Sul, Dae-Young Kang
1Department of Pathology, Eulji University Hospital, 24-14 Mok-dong, Jung-gu, Daejeon 301-808, Korea. phone330@emc.eulji.ac.kr
Yonsei Medical Journal
|March 6, 2003
Summary
Pulmonary sclerosing hemangioma (SH) is typically benign, but this case shows metastasis to regional lymph nodes. This highlights the importance of evaluating lymph node involvement in lung SH.
Area of Science:
- Pulmonology
- Surgical Oncology
- Pathology
Background:
- Pulmonary sclerosing hemangioma (SH) is a rare lung tumor, generally considered benign.
- Extremely rare instances of lymph node metastasis have been documented.
Observation:
- A 19-year-old female presented with a persistent cough and a large lower lobe lung mass on imaging.
- Surgical resection revealed a well-defined mass with metastasis to hilar, interlobar, and intrapulmonary lymph nodes.
- Histological analysis identified polygonal and cuboidal cells, both expressing EMA and TTF-1, with differential pancytokeratin expression.
Findings:
- Metastasis of pulmonary sclerosing hemangioma to regional lymph nodes was confirmed.
- Immunohistochemical markers (EMA, TTF-1, pancytokeratin) aided in characterizing the tumor cells.
Implications:
- This case underscores the necessity of assessing lymph node status in pulmonary SH, even if typically benign.
- The findings suggest that pulmonary SH may have a metastatic potential requiring careful evaluation and management.
- Further research into the metastatic potential and prognostic factors of pulmonary SH is warranted.