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Updated: Sep 27, 2026

Integrated Compensatory Responses in a Human Model of Hemorrhage
Published on: November 20, 2016
[Pathophysiology and principles of treating acute blood loss]
1Central Scientific Research Institute of Gastroenterology, Moscow.
The success of medical measures in case of acute hemorrhage depends substantially on the adequacy of determination of the volume deficiency of the circulating blood and its components as well as on the timely conduction of a pathigenetically grounded complex of infusion-transfusion therapy. Modern transfusiology has a great number of blood substitutes at its disposal, which allow fighting against acute hypovolemia with the minimal replacement of the blood loss with blood components. As there is no single remedy for treatment of acute hemorrhage, in each specific case it is necessary to select an adequate combination of transfusion media to conduct specific infusion-transfusion therapy.
The success of medical measures in case of acute hemorrhage depends substantially on the adequacy of determination of the volume deficiency of the circulating blood and its components as well as on the timely conduction of a pathigenetically grounded complex of infusion-transfusion therapy. Modern transfusiology has a great number of blood substitutes at its disposal, which allow fighting against acute hypovolemia with the minimal replacement of the blood loss with blood components. As there is no single remedy for treatment of acute hemorrhage, in each specific case it is necessary to select an adequate combination of transfusion media to conduct specific infusion-transfusion therapy.
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