Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

DNA replication: telling time with microarrays.

Heather J McCune¹, Anne D Donaldson

¹Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA.

|March 7, 2003

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Dysregulated Alternative Splicing in Breast Cancer Subtypes of RIF1 and Other Transcripts.

International journal of molecular sciences·2025

Same author

The human RIF1-Long isoform interacts with BRCA1 to promote recombinational fork repair under DNA replication stress.

Nature communications·2025

Same author

Checkpoint phosphorylation sites on budding yeast Rif1 protect nascent DNA from degradation by Sgs1-Dna2.

PLoS genetics·2023

Same author

Protection of nascent DNA at stalled replication forks is mediated by phosphorylation of RIF1 intrinsically disordered region.

eLife·2022

Same author

SAF-A promotes origin licensing and replication fork progression to ensure robust DNA replication.

Journal of cell science·2021

Same author

Protein phosphatase 1 acts as a RIF1 effector to suppress DSB resection prior to Shieldin action.

Cell reports·2021

Same journal

Integrated lipidomic and transcriptomic profiling of the host response in human malaria.

Genome biology·2026

Same journal

Centromeric satellite expansion drives genome evolution in the snowy owl.

Genome biology·2026

Same journal

Mapping the landscape of allele-specific expression in porcine genomes.

Genome biology·2026

Same journal

Genomic sequence evolution underlying human neocortical interareal diversification.

Genome biology·2026

Same journal

Regulatory mechanisms driven by functional 3'-UTR variants in alcohol use disorder and related traits.

Genome biology·2026

Same journal

A longitudinal single-nucleus transcriptomic atlas of bovine placentation reveals dynamic cellular hierarchies and regulatory programs.

Genome biology·2026

See all related articles

Eukaryotic DNA replication timing and gene activity are linked, but this relationship differs between yeast and higher eukaryotes like Drosophila. This suggests distinct regulatory mechanisms controlling replication and transcription in different organisms.

Area of Science:

Molecular Biology
Genetics
Cell Biology

Background:

A prevailing hypothesis links late-replicating DNA regions to transcriptional inactivity.
It's also hypothesized that inhibiting transcription delays DNA replication initiation.

Purpose of the Study:

To investigate whether replication timing and transcriptional activity are regulated differently in yeast versus higher eukaryotes.
To reconcile conflicting findings from yeast and Drosophila studies.

Main Methods:

Comparative analysis of existing research data from yeast and Drosophila.
Review of studies on DNA replication timing and transcriptional regulation.

Main Results:

Contrasting results suggest differential regulation of replication timing and transcriptional activity.

Related Experiment Videos

Yeast and Drosophila studies present divergent patterns in the relationship between these processes.

Conclusions:

The hypothesis that late replication exclusively correlates with transcriptional silence may not hold universally across eukaryotes.
Replication timing and transcriptional activity appear to be differentially regulated in yeast compared to higher eukaryotes, necessitating further investigation into specific mechanisms.