Related Experiment Video
Updated: Aug 11, 2026
15:17
Colorectal Cancer Cell Surface Protein Profiling Using an Antibody Microarray and Fluorescence Multiplexing
Published on: September 25, 2011
Predictive markers for colorectal cancer: current status and future prospects
Daniel B Longley1, Ultan McDermott, Patrick G Johnston
1Department of Oncology, Cancer Research Centre, Queen's University Belfast, Northern Ireland.
Clinical Colorectal Cancer
|March 7, 2003
Summary
Colorectal cancer (CRC) treatment faces challenges due to drug resistance. Identifying prognostic and predictive markers can help tailor chemotherapy, improving patient outcomes and treatment effectiveness.
Area of Science:
- Oncology
- Cancer Biology
- Pharmacogenomics
Background:
- Colorectal cancer (CRC) is a leading cause of cancer death in the US.
- Chemotherapy improves outcomes but is limited by drug resistance.
- 5-Fluorouracil remains a primary CRC treatment, with combinations showing improved response rates.
Purpose of the Study:
- To review prognostic and predictive factors in colorectal cancer.
- To discuss the potential of these markers in tailoring CRC treatment.
- To explore strategies for improving chemotherapy benefit in CRC patients.
Main Methods:
- Literature review of prognostic and predictive markers in CRC.
- Analysis of current chemotherapy regimens and their limitations.
- Discussion of emerging therapeutic targets and biomarkers.
Main Results:
- Intrinsic and acquired drug resistance limit chemotherapy efficacy in CRC.
- Newer agents like irinotecan and oxaliplatin improve response rates.
- Prognostic markers can identify patients likely to benefit from chemotherapy.
- Predictive markers may indicate response to specific chemotherapies.
Conclusions:
- Tailoring CRC treatment based on molecular profiles and biomarkers is crucial.
- Prospective identification of patients for chemotherapy can enhance response rates.
- Further research into prognostic and predictive factors will optimize CRC therapy.
More Related Videos
Related Concept Videos
02:07Tumor Progression
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
02:57Targeted Cancer Therapies
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
There are several types of targeted therapies against specific...