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Related Experiment Videos

Extracorporeal photopheresis technical aspects.

F Schooneman1

  • 1EFS Nord de France, 21 Rue Camille Guérin, 59012 Lille Cedex, France. francois.schooneman@efs.sante.fr

Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis
|March 7, 2003
PubMed
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Extracorporeal photochemotherapy (ECP) uses 8-methoxypsoralen (8-MOP) and ultraviolet A (UVA) light to treat diseases. This review analyzes ECP techniques, focusing on system evolution and future standardization needs for optimal therapeutic outcomes.

Area of Science:

  • Photomedicine
  • Immunomodulation
  • Dermatology

Background:

  • Extracorporeal photochemotherapy (ECP) is a well-established monotherapy for various conditions, developed in 1987.
  • The procedure involves treating 8-methoxypsoralen (8-MOP) loaded lymphocytes with ultraviolet A (UVA) radiation outside the body.

Purpose of the Study:

  • To analyze and compare different extracorporeal photochemotherapy techniques.
  • To discuss the evolution of ECP systems and identify areas for future standardization.

Main Methods:

  • Review of technical, biological, and hematological data from three ECP techniques: UVAR system, XTS apparatus, and the two-step method (continuous blood cell separator + UV-MATIC irradiator).

Main Results:

  • The UVAR system was the initial design; it has been succeeded by the automated XTS apparatus.

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  • An alternative method involves separate cell collection and irradiation steps, utilizing a blood cell separator and a UV-MATIC irradiator.
  • Analysis of technical, biological, and hematological parameters across these methods.

    • Conclusions:

    • Future research should focus on defining optimal UVA energy and 8-MOP concentrations.
    • Standardization of the ECP process, including the therapeutic dose of irradiated cells, is crucial for consistent clinical outcomes.